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In principle, responsivity can be decreased by inhibiting excitatory or activating inhibitory neurons. Most excitatory nerve cells utilize glutamate and most inhibitory neurons utilize ?-aminobutyric acid (GABA) as their transmitter.
Thus, the nitrates enable myocardial flow resistance to be reduced even in the presence of coronary sclerosis with angina pectoris. In angina due to coronary spasm, arterial dilation overcomes the vasospasm and restores myocardial perfusion to normal. |
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